3000480
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  Comprehensive Systemic Sclerosis Panel

SCL COMPRE
Example Reports
Negative
Positive

Ordering Recommendation

Comprehensive evaluation for systemic sclerosis (SSc) when suspicion for SSc is high and patient presents with features of overlap syndrome. For patients with distinct features of SSc, order Criteria Systemic Sclerosis Panel (3000479).

New York DOH Approval Status

This test is New York state approved.

Specimen Required

Patient Preparation
Collect

Serum separator tube (SST).

Specimen Preparation

Separate from cells ASAP or within 2 hours of collection. Transfer 3 mL serum to an ARUP standard transport tube. (Min: 1.5 mL)

Storage/Transport Temperature

Refrigerated. Also acceptable: Room temperature or frozen.

Unacceptable Conditions

Hemolyzed, hyperlipemic, icteric, heat-treated, or contaminated specimens

Remarks
Stability

Ambient: 48 hours; Refrigerated: 2 weeks; Frozen: 1 month

Methodology

Qualitative Immunoblot / Semi-Quantitative Indirect Fluorescent Antibody (IFA) / Semi-Quantitative Multiplex Bead Assay / Semi-Quantitative Enzyme-Linked Immunosorbent Assay (ELISA)

Performed

Thu

Reported

1-8 days

Reference Interval

Test Number
 Components
 Reference Interval
  Smith/RNP (ENA) Ab, IgG 40 AU/mL or less
  Scleroderma (Scl-70) (ENA) Antibody, IgG 40 AU/mL or less
  RNA Polymerase III Antibody, IgG 19 Units or less
  PM/Scl 100 Antibody, IgG Negative
  Fibrillarin (U3 RNP) Ab, IgG Negative
  Antinuclear Antibody (ANA), HEp-2, IgG Less than 1:80

Interpretive Data

  Refer to report.


Component
Interpretation
Scleroderma (Scl-70) (ENA) Antibody, IgG 29 AU/mL or less: Negative
30-40 AU/mL: Equivocal
41 AU/mL or greater: Positive
Smith/RNP (ENA) Antibody, IgG 29 AU/mL or less: Negative
30-40 AU/mL: Equivocal
41 AU/mL or greater: Positive
RNA Polymerase III Antibody, IgG 19 Units or less: Negative
20-39 Units: Weak Positive
40-80 Unit: Moderate Positive
81 Units or greater: Strong Positive

Compliance Category

Laboratory Developed Test (LDT)

Note

  Panel includes: Antinuclear Antibody (ANA) with HEp-2 Substrate, IgG by IFA, Scleroderma (Scl-70) (ENA) Antibody, IgG, RNA Polymerase III Antibody, IgG, Smith/RNP (ENA) Antibody, IgG, Fibrillarin (U3 RNP) Antibody, IgG, PM/Scl-100 Antibody, IgG by Immunoblot.

Hotline History

View Hotline History

 

Hotline History

Date of Change
Test Name Change
Methodology
Performance/Reported Schedule
Specimen Requirements
Reference Interval
Interpretive Data
Note
CPT Code
Component Change
Other Interface Change
New Test
Inactive
03/02/2026
X
X
N/A

CPT Codes

86039; 86235 x4; 83516

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Components

Component Test Code* Component Chart Name LOINC
0050470 Smith/RNP (ENA) Ab, IgG 33567-9
0050599 Scleroderma (Scl-70) (ENA) Antibody, IgG 47322-3
2001602 RNA Polymerase III Antibody, IgG 79182-2
2003041 PM/Scl 100 Antibody, IgG 81732-0
2012174 Fibrillarin (U3 RNP) Ab, IgG 49963-2
3000090 Antinuclear Antibody (ANA), HEp-2, IgG 21424-7
3000096 ANA Interpretive Comment 49311-4
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.

Aliases

Comprehensive Systemic Sclerosis Panel